VIP 10mg

Vasoactive Intestinal Peptide (VIP) is a 28-amino acid neuropeptide belonging to the glucagon/secretin superfamily. Widely distributed throughout the nervous and immune systems, VIP acts on VPAC1 and VPAC2 receptors to mediate vasodilation, immunomodulation, and circadian rhythm entrainment. Its pleiotropic activity across the gastrointestinal, pulmonary, and central nervous systems has positioned it as a compound of considerable translational research interest.

Molecular Information

Molecular Formula	C₁₄₇H₂₄₄N₄₄O₄₃S
Molecular Weight	3326.8 g/mol
Purity	≥98% (HPLC)
Appearance	White lyophilized powder
Storage Form	Lyophilized peptide
Storage Information	Store in a refrigerated environment free of exposure to sunlight, moisture, or excessive heat.

Mechanisms of Research Interest

VIP binds VPAC1 and VPAC2 receptors, activating adenylyl cyclase and elevating intracellular cAMP to produce smooth muscle relaxation, vasodilation, and immunomodulatory effects. It promotes anti-inflammatory cytokine profiles — notably IL-10 and TGF-β — while suppressing pro-inflammatory mediators such as TNF-α and IL-6. Neuroprotective effects have been observed in CNS inflammation models, and VIP has been identified as a key regulator of the suprachiasmatic nucleus circadian clock.

Research Applications

VIP 10mg supports research into pulmonary hypertension, autoimmune and neuroinflammatory disease models, circadian biology, gastrointestinal motility, and bronchodilation pharmacology. Its dual role as a neuropeptide and immunomodulator makes it broadly applicable across disciplines ranging from immunology to chronobiology.

Quality Assurance & Supplier Commitment

We maintain longstanding relationships with leading peptide lyophilizers and raw material suppliers, selected through an exhaustive vetting process that evaluates manufacturing practices, analytical capabilities, and regulatory compliance. Our API sourcing protocol includes certificate of analysis review, third-party analytical testing, and periodic supplier audits to ensure consistent purity, potency, and sterility standards across all product lines.

Each batch undergoes meticulous quality control verification prior to release, including HPLC purity analysis, mass spectrometry confirmation, and endotoxin testing where applicable. Our commitment to sourcing integrity ensures researchers receive material of the highest available quality.