DSIP 5mg

Delta Sleep-Inducing Peptide (DSIP) is a naturally occurring nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) first isolated from the cerebral venous blood of rabbits during slow-wave sleep induction experiments. Since its initial characterization, DSIP has been identified in the hypothalamus, limbic system, pituitary, adrenal glands, and peripheral tissues, suggesting a broad neuromodulatory and endocrine regulatory role extending well beyond sleep induction. Its amphiphilic structure enables blood-brain barrier penetration and interaction with multiple receptor systems, positioning it as a multi-target neuropeptide of considerable research interest.

DSIP’s activity profile spans sleep architecture regulation, hypothalamic-pituitary-adrenal (HPA) axis modulation, growth hormone secretion, antioxidant biology, and stress response normalization — making it one of the more versatile CNS-active peptides in the preclinical research toolkit. The 5mg vial supports intranasal delivery research, central nervous system pharmacology studies, and neuroendocrine pathway investigation.

Molecular Information

CAS Number	62568-57-4
Molecular Formula	C₃₅H₄₈N₁₀O₁₅
Molecular Weight	848.82 g/mol
Structure	Nonapeptide: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
Source	Naturally occurring — first isolated from rabbit cerebral venous blood
Strength	5 mg
Purity	≥98% (HPLC)
Appearance	White lyophilized powder
Storage Form	Lyophilized peptide
Storage Information	Store in a refrigerated environment free of exposure to sunlight, moisture, or excessive heat.

Mechanisms of Research Interest

DSIP modulates delta-wave (slow-wave) sleep induction through interaction with hypothalamic sleep-regulatory nuclei, including the ventrolateral preoptic area (VLPO) and sleep-active GABAergic circuits. It suppresses somatostatin secretion from the periventricular nucleus, effectively disinhibiting growth hormone-releasing hormone (GHRH) signaling and potentiating GH pulse amplitude — a mechanism studied in the context of both sleep architecture and somatotropic axis research.

HPA axis modulation represents a second major research focus. DSIP normalizes stress-induced elevations in corticotropin-releasing factor (CRF) and attenuates corticosterone release in preclinical stress models, suggesting a homeostatic role in stress response regulation rather than simple suppression. NMDA receptor interactions in sleep-related nuclei have been implicated in DSIP’s sleep-promoting activity, with research demonstrating modulation of glutamatergic transmission in circuits governing the sleep-wake transition.

Antioxidant activity in neuronal tissue has been documented across multiple in vitro models — including superoxide dismutase-like radical scavenging activity and attenuation of lipid peroxidation in CNS tissue preparations. Mitochondrial protective effects in neural cell models have been reported, supporting research interest in DSIP as a neuroprotective agent alongside its neuromodulatory properties. Opioid system interactions have also been studied, with evidence of enkephalin metabolism modulation contributing to DSIP’s stress-normalization and analgesic-adjacent research profile.

Research Applications

DSIP 5mg is used in sleep biology and delta-wave architecture research, HPA axis stress response modulation studies, GH secretion pathway investigation via somatostatin suppression, CNS antioxidant and neuroprotection models, NMDA receptor pharmacology in sleep circuits, neuroendocrine regulation research, intranasal neuropeptide delivery and nose-to-brain transport studies, enkephalin and opioid system interaction research, and mitochondrial neuroprotection investigation.

Quality Assurance & Supplier Commitment

We maintain longstanding relationships with leading peptide lyophilizers and raw material suppliers, selected through an exhaustive vetting process that evaluates manufacturing practices, analytical capabilities, and regulatory compliance. Our API sourcing protocol includes certificate of analysis review, third-party analytical testing, and periodic supplier audits to ensure consistent purity, potency, and sterility standards across all product lines.

Each batch undergoes meticulous quality control verification prior to release, including HPLC purity analysis, mass spectrometry confirmation, and endotoxin testing where applicable. Our commitment to sourcing integrity ensures researchers receive material of the highest available quality.

RESEARCH USE ONLY DISCLAIMER

This product is intended exclusively for in vitro research and laboratory use by qualified professionals. It is not approved for human or veterinary use, consumption, or therapeutic application. This product has not been evaluated by the FDA or any equivalent regulatory authority. The seller makes no claims regarding its safety, efficacy, or suitability for any medical, diagnostic, or therapeutic purpose. All research must comply with applicable local, state, and federal regulations.